Action tremor during object manipulation in Parkinson's disease
Identifieur interne : 001C64 ( Main/Exploration ); précédent : 001C63; suivant : 001C65Action tremor during object manipulation in Parkinson's disease
Auteurs : Hans Forssberg [Suède] ; Páll E. Ingvarsson [Suède] ; Nobuaki Iwasaki [Suède] ; Roland S. Johansson [Suède] ; Andrew M. Gordon [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2000-03.
English descriptors
Abstract
In previous studies of fingertip forces during precision grip in subjects with Parkinson's disease (PD), we observed regular oscillations in isometric force. The present study characterizes the nature of these oscillations. Fingertip forces were recorded from the index finger and thumb during precision grip‐lifts with a 300 g and 900 g object in 10 subjects with PD and 20 healthy control subjects. Fourier analysis confirmed that all subjects with PD exhibited force oscillations with a clearly definable frequency (∼7–11 Hz). Five of these subjects also exhibited a second lower frequency peak (∼5 Hz). Approximately half of the 20 control subjects displayed a single frequency peak (∼8–12 Hz), which was generally lower in amplitude than in the subjects with PD (representing enhanced physiological tremor), whereas the remaining control subjects had low‐amplitude, broad‐based spectra (representing physiological tremor). The amplitude of the force oscillations was higher for lifts with the heavier object in both the control subjects and subjects with PD. l‐Dopa resulted in a decreased tremor amplitude but did not influence the frequency. The force oscillations of the two opposing digits normal to the grip surfaces were in phase, whereas the oscillations tangential to the grip surfaces were often out of phase. The results suggest that the multipeaked force rate trajectories reported previously are caused by action tremor. The similarity of force oscillations in subjects with PD and healthy control subjects suggests common tremor‐generating mechanisms and supports the notion that the parkinsonian action tremor (AT) is an exaggerated form of physiological tremor. These findings provide insight into the impaired hand function observed in individuals with PD.
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DOI: 10.1002/1531-8257(200003)15:2<244::AID-MDS1007>3.0.CO;2-H
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-03">2000-03</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="244">244</biblScope><biblScope unit="page" to="254">254</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">493A30011DEF3F450CDFC0DFD3A67D7F9D26CE40</idno><idno type="DOI">10.1002/1531-8257(200003)15:2<244::AID-MDS1007>3.0.CO;2-H</idno><idno type="ArticleID">MDS1007</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action tremor</term><term>Force oscillations</term><term>Hand function</term><term>Parkinson's disease</term><term>Precision grip</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In previous studies of fingertip forces during precision grip in subjects with Parkinson's disease (PD), we observed regular oscillations in isometric force. The present study characterizes the nature of these oscillations. Fingertip forces were recorded from the index finger and thumb during precision grip‐lifts with a 300 g and 900 g object in 10 subjects with PD and 20 healthy control subjects. Fourier analysis confirmed that all subjects with PD exhibited force oscillations with a clearly definable frequency (∼7–11 Hz). Five of these subjects also exhibited a second lower frequency peak (∼5 Hz). Approximately half of the 20 control subjects displayed a single frequency peak (∼8–12 Hz), which was generally lower in amplitude than in the subjects with PD (representing enhanced physiological tremor), whereas the remaining control subjects had low‐amplitude, broad‐based spectra (representing physiological tremor). The amplitude of the force oscillations was higher for lifts with the heavier object in both the control subjects and subjects with PD. l‐Dopa resulted in a decreased tremor amplitude but did not influence the frequency. The force oscillations of the two opposing digits normal to the grip surfaces were in phase, whereas the oscillations tangential to the grip surfaces were often out of phase. The results suggest that the multipeaked force rate trajectories reported previously are caused by action tremor. The similarity of force oscillations in subjects with PD and healthy control subjects suggests common tremor‐generating mechanisms and supports the notion that the parkinsonian action tremor (AT) is an exaggerated form of physiological tremor. These findings provide insight into the impaired hand function observed in individuals with PD.</div></front></TEI><affiliations><list><country><li>Suède</li><li>États-Unis</li></country><region><li>Svealand</li><li>État de New York</li></region><settlement><li>New York</li><li>Stockholm</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="Suède"><region name="Svealand"><name sortKey="Forssberg, Hans" sort="Forssberg, Hans" uniqKey="Forssberg H" first="Hans" last="Forssberg">Hans Forssberg</name></region><name sortKey="Ingvarsson, Pall E" sort="Ingvarsson, Pall E" uniqKey="Ingvarsson P" first="Páll E." last="Ingvarsson">Páll E. Ingvarsson</name><name sortKey="Iwasaki, Nobuaki" sort="Iwasaki, Nobuaki" uniqKey="Iwasaki N" first="Nobuaki" last="Iwasaki">Nobuaki Iwasaki</name><name sortKey="Johansson, Roland S" sort="Johansson, Roland S" uniqKey="Johansson R" first="Roland S." last="Johansson">Roland S. Johansson</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Gordon, Andrew M" sort="Gordon, Andrew M" uniqKey="Gordon A" first="Andrew M." last="Gordon">Andrew M. Gordon</name></region><name sortKey="Gordon, Andrew M" sort="Gordon, Andrew M" uniqKey="Gordon A" first="Andrew M." last="Gordon">Andrew M. Gordon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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